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Symbol
Name
ID 		Dsp
desmoplakin
MGI:109611
Phenotype annotations related to cardiovascular system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Cardiomyocyte hypertrophy
Abnormality of the cardiovascular system
Right ventricular cardiomyopathy
Dilated cardiomyopathy
Sudden cardiac death
Ventricular tachycardia
Premature ventricular contraction
Ventricular fibrillation
Congestive heart failure
Palmoplantar erythema
Disease(s) Associated with DSP
arrhythmogenic right ventricular dysplasia 8
Carvajal syndrome

Mouse Phenotypes
cardiovascular system phenotype
abnormal myocardium layer morphology
abnormal myocardial fiber morphology
abnormal intercalated disk morphology
abnormal heart morphology
abnormal heart apex morphology
increased heart atrium size
abnormal subendocardium layer morphology
enlarged heart
abnormal heart left ventricle morphology
dilated heart ventricle
cardiac fibrosis
decreased ventricle muscle contractility
abnormal heart echocardiography feature
decreased heart rate
prolonged RR interval
irregular heartbeat
ventricular premature beat
abnormal impulse conducting system conduction
abnormal heart electrocardiography waveform feature
prolonged QRS complex duration
abnormal R wave
abnormal T wave
bundle branch block
increased response of heart to induced stress
ventricular cardiomyopathy
Availability Mouse Genotype
Dspem1(IMPC)Mbp/Dspem1(IMPC)Mbp
Dsprul/Dsprul
Dspem1Melr/Dsp+ *
Dsprul/Dsp+
Dsptm1Efu/Dsptm1Efu
Myl2tm1(cre)Krc/Myl2+  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory